123 Effects of a Saccharomyces Cerevisiae Fermentation Product-Supplemented Diet on Fecal Characteristics, Oxidative Stress, and Blood Gene Expression of Adult Dogs Undergoing Transport Stress
نویسندگان
چکیده
Abstract Previously, a Saccharomyces cerevisiae fermentation product (SCFP) was shown to positively alter fecal microbiota, metabolites, and circulating immune cell function of adult dogs. The objective this study measure the effects SCFP on characteristics, serum oxidative stress biomarkers, whole blood gene expression dogs undergoing transport stress. Sixteen pointer (8M, 8F; mean age = 8.35 y; BW 27.13 kg) were used in randomized crossover design study. All fed control diet for 4 wk, then randomly assigned or SCFP-supplemented maintain 11 wk. A 6-wk washout preceded second 11-wk experimental period with receiving opposite treatments. After fresh samples collected before after van 45 min. Change from baseline data (i.e., transport) analyzed using Mixed Models procedure SAS 9.4, P< 0.05 being significant 0.10 trends. Changes malondialdehyde 8-isoprostane:creatinine concentrations increased (P< 0.05) SCFP, but decreased Other markers unaffected by during Fecal dry matter percentage tended be affected 0.10) stress, reduced dogs, stable SCFP. characteristics Blood cyclooxgenase-2 myeloperoxidase mRNA Expression other genes These suggest that benefits feeding novel model are mediated more so suppressing innate activation than through decreasing lipid peroxidation.
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ژورنال
عنوان ژورنال: Journal of Animal Science
سال: 2022
ISSN: ['0021-8812', '1525-3163', '1525-3015', '1544-7847']
DOI: https://doi.org/10.1093/jas/skac247.116